tn80 replied: "Many women with PCOS are insulin-resistant and therefore take Metformin to improve this condition (I'm on it also). When your insulin levels are balanced, your other hormones are more likely to balance out, and you'll be more likely to ovulate (which many women with PCOS do not). I'm on a mesage board for women with PCOS who are trying to get pregnant and have been told that Metformin can increase the chance of ovulation 8x. It doesn't work for all women, so after you've been on it for a few months, your dr. will need to check if you're ovulating (by checking progesterone levels late in your cycle and/or doing an ultrasound). If you're not, the most common drug that women with PCOS are given to induce ovulation is Clomid. It's taken for about 5 days at the beginning of your cycle and is supposed to induce ovulation. There are different dosages, the most common to start off at is 50mg. If that doesn't work, after a few cycles, your dr. will probably increase the dosage to 100mg and then 150mg. Dependence has been shown for women who are on it for longer than 6 months, so if it hasn't worked for you by that time, your dr. might add another drug to it or put you on injectables. If you're put on it, your dr. will probably also monitor you while you're on it as it can case hyperstimulation of your ovaries (some dr's don't, you'd have to discuss it with him/her). As with many fertility drugs, there is a higher chance of multiples with Clomid. However, Clomid is one of the cheapest fertility drugs at about $25-$50 (depending on name brand or generic) for 5 pills. As for miscarriage, I've recently learned that the chance of a miscarriage occurring in someone with PCOS is 1:2 whereas in "normal" women, it's 1:5. There are different reasons for this. One is that the progesterone level can drop during pregnancy, leading the body to think its not pregnant anymore. Another reason is that women with PCOS often have long/irregular cycles. Therefore, the endometrium lining is thicker than usual, making it easier to miscarry. Yahoo! Groups has some really good groups for women with PCOS, including ones specifically for women who are trying to conceive. If you're interested, you can contact me to get the names. I'm active on two particular boards and have learned SO much in just a matter of months. Since everyone is going through basically the same thing, it's nice to know there are women out there who are going through the same thing or have gone through it and can provide insight or advice (or at the very least can be supportive). If you're interested in joining, you can contact me and I can give you the info. Good luck!"