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Ibuprofen Manufacturing Information
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Ibuprofen Manufacturing Information in Q&A
How do you know that the ibuprofen you buy in Germanhas the same percentage composition as the ibuprofen? ibuprofen, C13H18O2, this is manufactured in michigan contains 75.69% by mass carbon, 8.80% hydrogen, and 15.51%oxygen. if you buy some ibuprofen for a headache while you are on vacation in Germany, how do you know that it has the same percentage composition as the ibuprofen you buy at home?

petticrew105 replied: "I guess you really don't. Here we have the FDA that says the percent composition must be 80% or higher. In other countries they might be able to sell you stuff with lower percent composition. I know Canada goes as low as 75%."

if u buy some ibuprofen in germany how would you know it has the same % compositon as the one you buy at home? The ibuprofen, C13 H18 O2 that is manufactured in michigan contains 75.69% carbon, 8.80% hydrogen,and 15.51% oxygen.

mrzwink replied: "ibuprohen is the name ofthe substance, it is going to have the same ratio of carbon hidrogin and oxygen as at home, simply because the chemical formula you listed is the same. the only things that can differ when you buy your ibuprofen abroad, are: - the amount of active substances (aka. the strength of the pill) in the case of ibuprofen this is usually on the box in miligrams. in europe this is either 500mg or 1000mg. (stronger can be gotten with docters perscriptions) - the composition of the filler substance. pills usually only contain a very small portion of the 'active' substance. because this amount is impractical to administer, the substances are either desolved in oil, water or a solid stubstance (usually chalk, sometimes sugar) waxes, or other substance can also be used. these filler substance always differ per manufacterer. when in doubt, ask the pharmacist. most higher educated germans, especially medical ones, will speak decent enough english."

Does freezing a prescription pill or other drug likely make it ineffective? I left several prescriptions and over-the-counter medicines (ibuprofen, nyquil, albuterol inhaler) in a car for several days in single digit (8 F) cold-as-butt north dakota temeratures. Most things say "Store between 15-30 C or 59-86 F", but does it really do anything to freeze this stuff? Or are these just idle threats from the manufactures to cover their asses? Or could are the chemical compositions of these drugs likely to change? Thanks!

Yaybob replied: "I'm a physician. This subject has not come up for me before, and I could find no specific answer. But here's what I know about the physics, chemistry and pharmacology of pharmaceuticals and cold temperatures: They should be fine. Molecules survive rides on comets through near absolute zero temperatures and appear intact in meteorites. Also, amino acids have been found in large interstellar gas clouds in deep space. Very large molecules like DNA might not fare so well, although that's debatable, and irrelevant to the present question. It's heat plus time that is so damaging to chemicals. In the cold, chemistry slows or stops and chemicals break down less quickly. Fortunately, ibuprofen and Nyquil are inexpensive and easily replaced, so, even though they are likely to be good, you might replace them anyway. Test the albuterol inhaler to make sure that it still delivers the spray that you are used to, and that it helps wheezing as always. And I would keep any other prescription drugs that you might not have named if they are pricey since the risk is low that they have lost efficacy (effectiveness), and virtually zero that they have converted into something actually harmful."

jamus d woespuss replied: "the chemistry would not have changed however there is a tiny possibility that the inhaler contents could have become unhomogenized (unmixed) as long as u shake the container IMMEDIATELY before use, it will be ok"

iheart808 replied: "Not for small molecules, could denature some protein drugs in solution like insulin, but is unlikely to be worse than leaving them at room temperature. Coldness can condence (or sublime) water, so keeping open packets of drugs which are suseptable to hydrolysis may be a problem if you don't use them as soon as you take them out."

plenum222 replied: "I doubt those would be damaged. I think the main concern of the pharmaceuticals is to limit the damage that frozen water-ice crystals may cause to the individual molecules of the medications, but if they were in relatively air-tight containers they should be okay. Maintaining the temperature relatively constant would reduce the chance of some cooler-prefering bacteria or mold growing on the tablets which sometimes contains sugar, I think. The inhaler, I wouldn't know, except to say that as a child I frequently used inhalers on winter campouts in Massachusetts where our butts froze, too!"

Do creams with Ibuprofen as an active ingredient need FDA approval of some sort? I keep seeing lots of micro-packaged creams that have Ibuprofen as an active ingredient (Just search for "Ibuprofen Cream" to see what I am talking about), and I find it hard to believe that all of them have received FDA approval, if it is necessary. Is there a resource that clearly explains how to get approval, if it is needed, or a guide to whether or not one needs approval for the manufacture of and sale of similar products, or an "Idiots guide to FDA approval" sort of thing. Ok, more details (Might spur some ideas?) There are certain active ingredients that are somehow "exempt" based on their being well understood (for example, lists Lidocaine.), but there has to be an easier way of finding all of this out rather than reinventing the wheel. For example: I just can't believe somebody that small really got FDA approval, but I also don't believe they could be selling Ibuprofen cream for 10 years without some repercussions if it wasn't FDA approved...

atg28 replied: "Good question. There's two components to your question - the API and the transfer medium. The API has been established; ibuprofen is produced as a USP chemical with understood pharmacokinetics. The cream aspect has to be proven that the API can be delivered through the skin properly. Speaking to history, it took SmithKline-Beecham close to 10 years in approvals with the FDA to get the first nicotine patch on the market. There should be sections to the FDA website to show which generic product has been approved for transdermal delivery."

Chemistry homework question - GCSE AQA Additional Science higher level? Hi. Stuck on this question and thought you'd be able to help me. My teacher hasn't taught us anything on this so that's why I'm stuck. I'll put it here as it's written on the page: "Ibuprofen is used as a pain killer throughout the world. You might know it as Nurofen or Ibuleve. The traditional way to manufacture ibuprofen involved a lot of chemical reactions and produced a lot of waste products. The atom economy was just 32%. Recently it became possible for any pharmaceutical (drug) company to make ibuprofen. As there was a lot of money to be made, the race was on to find the most economic way to make it. This meant cutting down waste products. The new method involves catalysts, some of which can be completely recovered and do no go out as waste. The atom economy is increased to 77%, partly because only the active form of ibuprofen is made. This also means that lower doses are needed and they take a shorter time to kill any pain. Evaluate the two methods of manufacture in terms of social, economic and environmental issues involved." [Higher] This question is worth 6 marks. Thanks :)

ldlk replied: "for 6 marks make two points on each area of the question, one point on each area per method of manufacture. dont let yourself get bogged down in the words its all fairly simple. economic its clear that its cheaper and more efficient to manufacture the second method and generates the most profit for the companies. environmentally the second is better since there is less waste. socially the second is better since it kills the pain more quickly and shuld be available more cheaply than the other. elabourate on the what ive written"

Getting sinus headach from working in menthol factory? I work in a tobacco manufacturing facility. The tobacco never bothers me until the machines run menthol cigarettes. The pressure in behind the eyes. I have no runny nose or sneezing or anything else but a headache. I have taken most pills but nothing will have any effect on the pain. I've taken aleve,tylenol,asperin,bendryl.ibuprofen but to no avail. Any help would be greatly appreciated.

tranquil replied: "The menthol odor might be too much for you. Please wear a good-fitting mask (N95 or better) to minimize breathing in the menthol."

Same % composition ? The ibuprofen, C13H18O2, that is manufactured in Michigan contains 75.69% carbon, 8.80% hydrogen, and 15.51% oxygen. If you buy some ibuprofen for a headache while you are on vacation in Germany, how do you know that the ibuprofen you buy at a pharmacy overseas has the same percentage composition as the one you buy at home?

inquisitivebob replied: "IBUPROFEN is the name given to a certain chemical structure. I wouldn't worry too much about % composition; I'm not a chemists but %composition could be misleading because something in the same ratio does not necessarily have to hold the same shape. And shape is really what your interested in terms of drugs like this. I think it works as a competitve inhibitor but i could be wrong."

three quick questions please help? 1. Aspirin is known to inhibit blood clotting. Explain why surgeons recommend that no aspirin be take immediately before of after surgery. 2. Explain why different pain relievers are manufactured and sold. 3. Predict the possibility of other medicines that might have the same common structural shape, as aspirin, acetaminophen, and ibuprofen.

Dragon Prince replied: "1. If you take Aspirin after surgery your blood will have an elevated level of anti-coagulants and therefore blood wouldn't clot. The result of this would be 2 fold: (a) the wound won't heal and (b) if the blood doesn't clot then the patient will bleed. 2. Different pain relievers are aimed at blocking different pain receptors, thus they are effective in different ways but inevitably have the same effect. 3. No idea possibly paracetamol"

Lost in Maryland replied: "First of all during surgery if your blood does not clot then you could bleed to death. Second question is because not everyone can take aspirin or vice versa not everyone can tolerate ibuprofen. Third question, I don't have a clue."

jvrmlln replied: "#1 is the only one i can answer. if you take it before surgery, it will be harder to stop you from losing too much blood during the procedure. if you take it after, if you have an internal bleed you may have bled too much before the bleed is discovered and you may not recover."

Bonnie L replied: "Because if your blood won't clot you could bleed to death. Effectiveness for different people, purpose, MONEY. Pills come in all shapes and sizes. It's definitely easy to create innumerable items in those shapes and sizes. They could drop everything into the same "caplet" wouldn't that be fun."

dna replied: "1. it is NSAID so it causes salt and water retention so it may cause hypertension which should be avoided in this case. 2.some people suffer from severe pain and the disease could not be cured like most terminal cancers so a pain reliever should be used, or due u want these patients to suffer for the little time remaining in their lives. 3.diclofenac(voltarin)"

W W D replied: "1. This one's pretty self-evident. Surgery involves cutting, and clots have to form in the cut tissue. Surgeons don't like excessive bleeding, which is a common enough complication to begin with. 2. Different pain relievers are sold to make a profit for the manufacturer. There's significant competition for market share. They're bought for a variety of reasons. One is individual variation. One person really will get better analgesia from drug A when another finds drug B better for the same pain/ same problem. Another is side-effect profile. A person with a history of recurrent bleeding ulcers will tend to choose acetaminophen over aspirin, where a person with advanced liver disease may be leery of taking acetaminophen and be better served taking ibuprofen. When neither of the above is a great reason for a choice, people are greatly swayed by advertising. I can't tell you how often I have a patient who has stomach pains, perhaps caused by ibuprofen, and uses ibuprofen to treat it because they've been swayed by what's on TV. 3. There's little reason for prediction when there are several salicylates on the market. And don't forget about ketoprofen. It's been done."

private15ft replied: "1. excessive bleeding possibly 2.More money for Big Pharma 3.smoke and mirrors by big pharma."

maur911 replied: "Aspirin can cause bleeding in the gut/stomach....acetaminophen and ibuprofen can cause leaky gut or perforate the intestines! You are better using natural vitamin E to prevent clotting and thinning the blood. Aspirins should not be taken for a few days before surgery to prevent serious bleeding."

chemistry its a weird question? the iburprofen, C13H18O2, that is manufactured in Michigan contains 74.69% carbon, 8.80% hydrogen, & 15.51%oxygen. if you buy some ibuprofen for headache while you are on vacation in Germany, how do you know that the ibuprofen you buy at a pharmacy overseas has the same percentage composition as the one you buy at home?

TurtleFromQuebec replied: "It's the same chemical compound, so it has the same chemical composition. The effect might depend to some extent on the presence of impurities, or additives that the different manufacturers put in."

Deborah P replied: "Ibuprofen has a fixed composition. Every time you buy ibuprofen, you are buying C13H18O2. If it has a different percent composition, it doesn't have the same chemical formula, so it isn't ibuprofen. Look at the law of definite proportions (http://en.wikipedia.org/wiki/Law_of_constant_composition)."

Nature Boy replied: "Ibuprofen is a molecule with the composition C13H18O2. If it had a different composition, it wouldn't be the same molecule so it wouldn't have the name ibuprofen. If you buy ibuprofen in Germany, you can be sure that it has exactly the same chemical composition as ibuprofen bought anywhere else."

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