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Warfarin Overdose

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What organs can be affected by an overdose of Warfarin. Usual dose 5mg however received 10 mg for 30 days.? I recently admitted my mother to a seniors residence for 2 months to take a vacation. She was rushed to hospital in a non responsive state 39 days later bleeding from the rectum and a very low blood count. She has had 8 transfusions and finally starting to come around. Her heart is too weak for doctors to examine internally where the bleeding was coming from. Her warfarin levels were extremely high at admission and the number of pills left in the bottle received from the residence indicate that she received 2 per day (10mg) instead of the prescribed one (5mg) for at least 30 days. I'd like to know how bad the damage to her other organs could potentially be from this overdose. She is now blind as well.

orangenyellow_roses replied: "I personally would look into hiring a lawyer as well to sue the seniors residence. That is outrageous, and could have been fatal. I see med errors all the time, I work in a hospital. Your mother will be ok now that she's recieving the proper dosage and the PT and INR levels are checked on a regular basis. Being on coumadin requires frequent monitoring of her blood levels. Her INR level should be between 2 and 3 at all times which is ideal. The main concern with coumadin is internal bleeding. Her organs should be ok. The blindness may or may not be related to the coumadin overdose. If she's diabetic that also may not have been monitored properly in the facility which is likely the case and could be the cause of blindness."

DT replied: "Her liver and kidneys can be damaged not to mention risks of internal bleeding. I agree get a lawyer and move her to a place with more compotent doctors/nurses if possible. Good luck."

Debbie replied: "ALL organs can be affected. I take coumadin for years due to various health issues. What it does is thin the blood. That's why it must be checked regularly. To make sure it doesn't get too thin. If it gets too thin, you will hemmorrrage and can bleed to death internally. If it's (your blood) too thick, it is not therapeutic in it's action and a clot will result. Very dangerous medicine. Oh, by the way, did you know that warfarin sodium(coumadin) is what is the only ingredient in rat poison. (Look at label) The rat eats it and bleeds to death internally eventually. I would get an attorney and report this place to the state too. Mistakes made once are common, but for this long is negligence."

Dave S replied: "IT DOES NOT THIN the blood....... it effects the coagulation time of blood. Please answer corectly"

W W D replied: "It's not so much a question of what organs warfarin can affect as it is a question of into what organs did she bleed. If the blindness is new, it's possible she bled into the eyes or the visual portion of the brain. The intestinal tract is probably not damaged, but still needs investigation when her health permits. I suspect they may have already done some brain imaging study and other tests, and the physicians in hospital should be able to give you a good idea of what you're dealing with."

Is it an overdose of warfarin and clexane? My grandfather has developed haematomas in his legs causing him much pain and return trip to the hospital after being discharged for only 4 days. The doctors now say that they might have given him a wrong amount of medication. He is now unable to walk. He is 72 years of age and has 30% renal ability left. He was prescribed Clexane 10mg/0.1mL via injection at 0.6ml every morning as well as Warfarin in tablet form at 2.5 mg everyday except a 3 mg dose on Sunday. Please help us with this. I will be meeting his doctors tomorrow and they said that we are to be prepared but we are not experts on this. Thank you so much. They said they might have given him too much, causing his red blood cell level to drop. Thanks.

michael k replied: "While i work in the medical field I don't believe i'm qualified to advise you on this type of treatment. I suffer with a similar medical problem myself. When i've had this problem with those same medications my doctors simply adjusted the dosage and it corrected the problem and i'm quite alot younger than your grandfather and in above average healthwise. However, you need to understand that your grandfather is 72 and age and health condition may have something to do with the affects the medication is having on him. See the doctors tomorrow tell them they need to be more aggressive of the treatment for your grandfather, if within 10 days he doesn't improve with their changes then perhaps seeking a second opinion from another doctor would be warranted."

Gracinda replied: "both of those medications "thin" the blood, in different ways. commonly called blood thinners. there are ways to reverse the effects of these medications, which can be used in some situations, like giving Vitamin K or platelets. Your grandfather's specific medical condition will determine how the doctors can to treat him. It is tricky to dose these medications, especially with someone who has an extensive medical history."

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